University of Chicago · NeuroscienceGomez Calcium Lab
Christopher Manuel Gomez · Chicago, Illinois
Research Focus
Dr. Christopher Manuel Gomez's lab at the University of Chicago focuses on understanding calcium channel gene disorders, which often lead to severe neurological issues. Their research delves into how mutations in these genes can result in different neuronal outcomes by studying the dual role of calcium channel genes—both as channel proteins and newly discovered transcription factors. The lab aims to develop innovative therapies that target the underlying biological mechanisms of these disorders.
calcium channelstranscription factorsmutationsneuronal developmentgene therapy
Research Aims
5AIM 01Identify how mutations in calcium channel genes disrupt neuronal function.
AIM 02Explore the regulatory mechanisms of bicistronic calcium channel genes.
AIM 03Investigate the role of transcription factors in neuronal physiology.
AIM 04Develop therapeutic strategies based on gene expression understanding.
AIM 05Utilize transgenic mice to model neurological disorders related to calcium channels.
Skills the Lab Values
PCRcell culturemouse modelsimmunoblottingimmunofluorescent microscopyfluorescent taggingviral vector designdual luciferase assaysnext-generation sequencingRNA interference
Output against the department
Publications248top 30% of dept.198th of 671
this lab
most publishedleast published
Citations10.0ktop 40% of dept.270th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.