Oregon Health & Science University · GeneticsNucleolar Insights Lab
Mu-Shui Dai · Portland, Oregon
Research Focus
Dr. Mu-Shui Dai's lab at Oregon Health & Science University focuses on understanding how a protein called USP36 regulates the nucleolar RNA exosome, which is crucial for ribosome production in cells. The lab studies how disruptions in this regulation can lead to cancer, particularly breast cancer. By exploring the biochemical mechanisms behind this process, the lab aims to identify potential therapeutic targets for cancer treatment.
ribosome biogenesiscancerRNA processingUSP36SUMOylation
Research Aims
3AIM 01Investigate how USP36 interacts with the nucleolar RNA exosome.
AIM 02Determine the role of USP36 in rRNA processing and ribosome biogenesis.
AIM 03Assess the impact of USP36 on cancer cell proliferation and tumor development.
Skills the Lab Values
cell culturemouse modelsbiochemical assaysmass spectrometryRNA sequencing
Output against the department
Publications110bottom 34% of dept.171st of 259
this lab
most publishedleast published
Citations4.9kbottom 27% of dept.189th of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.