University of California-Los Angeles · BiochemistryBhaduri Lab
Aparna Bhaduri · Los Angeles, California
Research Focus
Dr. Aparna Bhaduri's research lab at UCLA focuses on understanding how the human brain develops, particularly the processes that determine the specific types of cells formed in different brain areas. By studying how these processes go awry in conditions like neurodevelopmental disorders, the lab aims to improve models for brain development and potentially find new approaches to treat these disorders.
human brain developmentcortical organoidsneurodevelopmental disordersgene expressioncell fate specification
Research Aims
5AIM 01Investigate the signals that drive cortical arealization and laminar identity in the developing human brain.
AIM 02Identify novel transcriptional regulators influencing cell fate specification using bioinformatics.
AIM 03Utilize CRISPR to activate genes related to cortical development.
AIM 04Characterize the permanence of specification factors through knockdown experiments.
AIM 05Model neurodevelopmental disorders using improved cortical organoid systems.
Skills the Lab Values
CRISPRbioinformaticscell culturesingle-cell RNA sequencingtranscription factor assays
Output against the department
Publications211top 38% of dept.151st of 402
this lab
most publishedleast published
Citations15ktop 32% of dept.128th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.