University of Florida · PhysiologyLaitano Muscle Lab
Orlando Laitano · Gainesville, Florida
Research Focus
Dr. Orlando Laitano's lab at the University of Florida focuses on understanding and treating muscle weakness and dysfunction caused by sepsis, a severe infection that can lead to significant muscle loss and impairment. The research aims to identify the role of specific enzymes in this process and test new strategies to promote muscle recovery in affected patients. By exploring how sepsis affects muscle cells, the lab hopes to develop better therapeutic approaches to enhance recovery in critically ill patients.
sepsismuscle weaknessreactive oxygen speciesmuscle regenerationNADPH oxidase
Research Aims
4AIM 01Identify the role of NADPH oxidases in sepsis-induced muscle atrophy.
AIM 02Investigate the effects of targeting NOX2 and NOX4 on muscle function during sepsis.
AIM 03Examine the impact of sepsis on satellite cell function and muscle regeneration.
AIM 04Develop therapeutic strategies to enhance muscle recovery in septic patients.
Skills the Lab Values
animal modelsgene targetingmolecular biology techniqueshistological analysisproteomicsin vivo imagingcell cultureWestern blotRNA sequencing
Output against the department
Publications143bottom 47% of dept.151st of 286
this lab
most publishedleast published
Citations2.4kbottom 16% of dept.240th of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.