University of Washington-Seattle Campus · GeneticsBrewer Lab
Bonita J Brewer · Seattle, Washington
Research Focus
Dr. Bonita J. Brewer's lab at the University of Washington focuses on understanding how cells replicate their DNA accurately. By studying simple organisms like baker's yeast, the lab investigates the coordination between DNA replication and different cell cycle events, which is crucial for maintaining genome stability. Their work is particularly relevant to understanding human diseases, including cancer, that can arise from errors during DNA replication.
DNA replicationeukaryotic cellscell cyclegenome stabilitycancer researchSaccharomyces cerevisiaeribosomal RNAorigin regulationgenetic analysiscellular mechanisms
Research Aims
5AIM 01Investigate how rDNA replication is regulated in eukaryotes.
AIM 02Determine how rDNA copy number affects genome stability.
AIM 03Explore how origin preference influences DNA replication timing across the genome.
AIM 04Analyze the impact of replication choreography on cell cycle events.
AIM 05Examine the relationship between disruptions in DNA replication and human disease phenotypes.
Skills the Lab Values
DNA extractiongenetic manipulation of yeastchromosome structure analysisPCRWestern blotcell culture techniquesgenome sequencingbioinformaticsdata analysisspatiotemporal modeling
Output against the department
Publications92bottom 28% of dept.187th of 259
this lab
most publishedleast published
Citations8.4kbottom 45% of dept.143rd of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.