Iowa State University · BiochemistryThe T Cell Nexus
Amy H Andreotti · Ames, Iowa
Research Focus
Dr. Amy H Andreotti's lab focuses on understanding the signaling pathways that control T cell activation and differentiation, which are crucial for immune responses to infections and cancer. The lab aims to uncover how variations in T cell receptor (TCR) signaling strength affect gene expression and ultimately influence the behavior of T cells. By exploring the role of the ITK kinase, the lab seeks to improve therapeutic strategies related to autoimmune diseases and cancer.
T cell signalingITK kinaseautoimmunitycancer therapeuticsgene expression
Research Aims
3AIM 01Investigate the specific activation mechanisms of ITK in T cells.
AIM 02Examine costimulatory interactions that influence T cell responses.
AIM 03Explore the implications of ITK regulation in human diseases.
Skills the Lab Values
molecular biology techniquesbiochemical assayscell cultureflow cytometryWestern blotting
Output against the department
Publications171top 50% of dept.202nd of 402
this lab
most publishedleast published
Citations4.2kbottom 24% of dept.307th of 402
this lab
most citedleast cited
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