Yale University · BiologyRodeheffer Obesity Lab
Matthew S Rodeheffer · New Haven, Connecticut
Research Focus
Dr. Matthew Rodeheffer's lab at Yale University focuses on understanding the mechanisms behind obesity and its related diseases. The research particularly explores how the communication between endothelial cells and fat cells contributes to the accumulation and function of fat tissue. By studying hormones like estrogen and glucocorticoids in this context, the lab aims to develop new therapeutic strategies to combat obesity and associated metabolic disorders.
obesityadipocyte hyperplasiaendothelial cellsestrogenglucocorticoidsmetabolic diseaseadipose tissuehormonal regulationfat distribution
Research Aims
5AIM 01Investigate the role of estrogen produced by adipose tissue in obesity-related metabolic diseases.
AIM 02Examine how glucocorticoids regulate aromatase expression in endothelial cells of visceral fat.
AIM 03Define the molecular mechanisms by which estrogen influences adipocyte precursors.
AIM 04Analyze the obesity-specific mechanisms of adipogenesis and their sex-specific patterns.
AIM 05Develop novel therapeutic approaches targeting adipocyte function and obesity.
Skills the Lab Values
cell culturemouse modelsWestern blotRNA sequencingimmunohistochemistrymultiplexed imaginggenotypingPCRdata analysismetabolic profiling
Output against the department
Publications63bottom 17% of dept.860th of 1,033
this lab
most publishedleast published
Citations6.9kbottom 48% of dept.540th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.