Vanderbilt University · PhysiologyBeta Cell Adaptation Lab
Rafael Arrojo E Drigo · Nashville, Tennessee
Research Focus
Dr. Rafael Arrojo E Drigo's lab at Vanderbilt University focuses on understanding how beta cells, which produce insulin, adapt to various stresses like aging and nutritional changes. They investigate the underlying mechanisms of beta cell function and identity during these adaptations, using advanced techniques to explore their genetic and epigenetic landscapes. This research has important implications for improving treatment strategies for type 2 diabetes and enhancing beta cell longevity.
beta cellinsulindiabetescaloric restrictionepigeneticscell stressmetabolic healthaginggene transcription3D genomics
Research Aims
5AIM 01Investigate the mechanisms of beta cell adaptation to caloric restriction and ER stress.
AIM 02Study the spatial organization of the beta cell epigenome in response to metabolic demands.
AIM 03Determine how aging affects beta cell functionality and identity.
AIM 04Explore the relationship between beta cell heterogeneity and gene transcription at the single-cell level.
AIM 05Assess the effects of different diets on beta cell longevity and insulin secretion.
Skills the Lab Values
single cell transcriptomicsmicroscopy techniques (light and electron)data analysis using bioinformaticsmouse models developmentgene expression profilingepigenetic assaysin vivo cellular function assessment3D cell imaging
Output against the department
Publications55bottom 9% of dept.261st of 286
this lab
most publishedleast published
Citations2.5kbottom 18% of dept.235th of 286
this lab
most citedleast cited
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