University of California-Los Angeles · NeuroscienceRexach Lab
Jessica E Rexach · Los Angeles, California
Research Focus
Dr. Jessica E Rexach's lab focuses on understanding the role of interneurons in Alzheimer’s disease and related dementias using innovative stem cell models. The lab creates assembloids derived from human induced pluripotent stem cells (iPSCs) to mimic the complex interactions between different types of brain cells, particularly how mutations in the tau protein affect cognitive decline. By studying how these cells work together, the lab aims to uncover potential pathways for developing new treatments and improving clinical trials.
Alzheimer's diseasetau proteininterneuronsiPSC modelsdementiacognitive declinebrain circuitsstem cell researchneurodegeneration
Research Aims
5AIM 01Validate a stem cell model that reflects interneuron physiology in Alzheimer's disease
AIM 02Explore how tau mutations affect neurotransmission in the hippocampus
AIM 03Study the interaction between interneurons and disease mechanisms
AIM 04Identify new phenotypic endpoints for cognitive decline
AIM 05Develop a platform for drug development targeting neurodegenerative diseases.
Skills the Lab Values
iPSC cultureassembloid generationelectrophysiologymolecular phenotypinggenetic mutation analysisdata visualizationcellular signaling assaysneuron connectivity mappingdrug discovery techniques
Output against the department
Publications55bottom 13% of dept.584th of 671
this lab
most publishedleast published
Citations2.2kbottom 14% of dept.579th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.