Columbia University in the City of New York · PharmacologyConcepcion Oncology Lab
Carla P Concepcion · New York, New York
Research Focus
Dr. Carla P. Concepcion's lab focuses on developing innovative therapies for a specific type of lung cancer that lacks effective treatments. Her research targets the SMARCA2 gene, which plays a critical role in the growth of tumors that have lost another important gene called SMARCA4. By studying genetically engineered mice, her team is investigating how to effectively degrade SMARCA2 to inhibit cancer development and exploring how the immune system can help in these treatments. This work aims to provide new hope for patients with this aggressive form of lung cancer.
lung cancerSMARCA2geneticstherapeuticstumor microenvironmentepigeneticsgenetically engineered mouse modelscancer progressioncombination therapy
Research Aims
3AIM 01Investigate the effects of SMARCA2 degradation on tumor progression in lung cancer models.
AIM 02Determine the mechanisms underlying the relationship between SMARCA2 and SMARCA4.
AIM 03Develop combinatorial treatment approaches utilizing the immune microenvironment for lung cancer therapies.
Skills the Lab Values
genetic engineeringmouse modelsCRISPRepigenetic analysistumor growth assessmentimmune profilingcell cultureflow cytometrydrug delivery systems
Output against the department
Publications68bottom 14% of dept.398th of 462
this lab
most publishedleast published
Citations2.3kbottom 16% of dept.389th of 462
this lab
most citedleast cited
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