University of Toledo · BiologyTumor Immunology and Biomarker Lab
Jianmin Zhang · Toledo, Ohio
Research Focus
Dr. Jianmin Zhang's lab at the University of Toledo focuses on understanding the complex interactions between tumors and the immune system, specifically in triple-negative breast cancer (TNBC). The lab investigates how a protein called TAZ influences the behavior of immune cells in the tumor environment, potentially leading to new targets for treatment in this aggressive form of breast cancer. Their research aims to uncover mechanisms that could improve patient outcomes by identifying novel biomarkers and therapeutic strategies.
triple-negative breast cancerTAZtumor microenvironmentmyeloid-derived suppressor cellsimmunotherapyimmune suppressioncancer biologycytokinesmetastasisbiomarkers
Research Aims
3AIM 01Determine the impact of tumor-intrinsic TAZ expression on the immune-tumor microenvironment in preclinical models of TNBC.
AIM 02Investigate the molecular mechanisms by which tumor-intrinsic TAZ expression recruits myeloid-derived suppressor cells to the tumor microenvironment.
AIM 03Assess the relationship between tumor TAZ expression and the immune-tumor microenvironment in patients with TNBC.
Skills the Lab Values
cell culturemouse modelsmass cytometryRNA sequencingprotein analysisbiochemical assaysimmunohistochemistryflow cytometrydata analysis in cancer researchclinical trial design
Output against the department
Publications553top 6% of dept.64th of 1,033
this lab
most publishedleast published
Citations18ktop 22% of dept.232nd of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.