University of Arizona · PharmacologyValley Fever Immunology Lab
Yin Chen · Tucson, Arizona
Research Focus
Dr. Yin Chen's lab at the University of Arizona focuses on understanding how our immune system responds to Coccidioides, the fungus responsible for Valley Fever. With cases of this serious infection rising, the lab studies how special proteins in our lungs can fight off this pathogen, even in healthy individuals. By exploring these mechanisms, their research aims to find new ways to treat and prevent this disease, which poses a significant health risk.
CoccidioidesCoccidioidomycosisinnate immunityantimicrobial proteinsfungal infectionslung healthpathogen responseepithelial biologyantifungal therapypublic health
Research Aims
5AIM 01Investigate the innate immune responses to Coccidioides infection.
AIM 02Identify the roles of airway epithelial antimicrobial proteins SCGB1A1 and BPIFA1.
AIM 03Understand how BPIFA1 functions to combat Coccidioides.
AIM 04Explore the regulation of BPIFA1 secretion by SCGB1A1.
AIM 05Develop insights for novel antifungal therapies based on immunological responses.
Skills the Lab Values
mouse modelscell culturein vitro studiesmolecular biology techniquesprotein analysisimmunological assaysBSL3 containment proceduresextracellular vesicle productiongene expression analysisexperimental design
Output against the department
Publications639top 6% of dept.26th of 462
this lab
most publishedleast published
Citations20ktop 18% of dept.84th of 462
this lab
most citedleast cited
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