University of Pennsylvania · BiologyLiver Cell Organization and Division Lab
Erfei Bi · Philadelphia, Pennsylvania
Research Focus
Dr. Erfei Bi's lab at the University of Pennsylvania focuses on understanding how liver cells (hepatocytes) organize themselves and how they divide. The research aims to explore the formation of bile canaliculi, which are essential for liver function and can impact liver diseases. Additionally, the lab investigates the cytoskeleton's role in cell division, which has implications for various diseases, including cancers and neurodegenerative disorders.
hepatocyte polarizationbile canaliculuscytokinesisseptin cytoskeletoncell divisionliver diseasescell migrationsuper-resolution microscopy
Research Aims
3AIM 01Investigate the mechanisms of hepatocyte polarization and bile canaliculus formation.
AIM 02Determine the roles of actin-binding proteins in junction assembly.
AIM 03Explore the interaction of polarity regulators in apical trafficking.
Skills the Lab Values
cell culturemicroscopyCRISPRgenetic editingbiochemical analysisimaging technologiesprotein purificationRNA sequencinganimal models
Output against the department
Publications108bottom 37% of dept.645th of 1,033
this lab
most publishedleast published
Citations11ktop 34% of dept.351st of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.