Yale University · PharmacologyWNT Signaling Dynamics Lab
Mark A Lemmon · New Haven, Connecticut
Research Focus
Dr. Mark A. Lemmon's lab focuses on understanding unique signaling mechanisms used by unusual receptor tyrosine kinases (RTKs) that play critical roles in various human diseases, including cancer and congenital defects. The research aims to uncover how these receptors, particularly those involved in WNT signaling, can function without the traditional activation methods used by most RTKs. This innovative approach may lead to the discovery of new ways to treat conditions linked to these poorly understood receptors.
Receptor Tyrosine KinasesWNT SignalingNeurodevelopmental DisordersBone DiseasesCancer ResearchPseudokinasesTherapeutic TargetingSignal TransductionMolecular Crystallography
Research Aims
5AIM 01Investigate the signaling mechanisms of non-canonical receptor tyrosine kinases.
AIM 02Uncover the role of pseudokinases in WNT signaling pathways.
AIM 03Determine structural dynamics of RTKs using crystallography and electron microscopy.
AIM 04Explore therapeutic potentials of targeting pseudokinase RTKs in human diseases.
AIM 05Understand the differences in mechanism between canonical and non-canonical RTKs.
Skills the Lab Values
Protein CrystallographyMolecular ModelingCell Culture TechniquesKinase Inhibitor AssaysStructural BiologyExtracellular Domain AnalysisSignal Transduction AssaysDrug DesignBiomolecular InteractionsHigh-Resolution Imaging
Output against the department
Publications337top 22% of dept.102nd of 462
this lab
most publishedleast published
Citations35ktop 8% of dept.35th of 462
this lab
most citedleast cited
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