University of Connecticut · BiologyDodge-Kafka Calcium Lab
Kimberly L Dodge-Kafka · Storrs, Connecticut
Research Focus
Dr. Kimberly L Dodge-Kafka's lab at the University of Connecticut focuses on understanding how specific calcium signaling pathways contribute to heart conditions, particularly cardiac hypertrophy. The lab is investigating how calcium microdomains affect signaling in heart cells and aims to develop new treatments for heart disease by targeting these pathways. Their research emphasizes the role of certain protein complexes in regulating calcium signals that can lead to heart remodeling and failure.
calcium signalingcardiac hypertrophyheart diseasecalcium microdomainsmAKAPbprotein phosphatasemyocyte physiologytherapeutic targetssignal transduction
Research Aims
3AIM 01Demonstrate that mAKAPb-signalosome associated RyR2 regulates myocyte hypertrophy independent of E-C coupling.
AIM 02Map the perinuclear calcium domain specified by the mAKAPb signalosome.
AIM 03Investigate the therapeutic potential of targeting perinuclear RyR2 in mouse models of cardiac hypertrophy.
Skills the Lab Values
cell culturemouse modelsWestern blotRNA sequencingfluorescence resonance energy transfer (FRET)molecular cloningpharmacological manipulationprotein analysisgene expression assays
Output against the department
Publications60bottom 15% of dept.872nd of 1,033
this lab
most publishedleast published
Citations2.2kbottom 15% of dept.875th of 1,033
this lab
most citedleast cited
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