University of Colorado Boulder · GeneticsDown Syndrome and Neurodegeneration Lab
Charles A Hoeffer · Boulder, Colorado
Research Focus
Dr. Charles Hoeffer's lab at the University of Colorado is focused on understanding how genetic factors in Down syndrome (DS) contribute to sleep problems and their relationship with Alzheimer’s disease (AD). They investigate specific genes that may disrupt sleep and worsen cognitive impairments, aiming to uncover the mechanisms behind these issues to improve quality of life for individuals with DS. Overall, this research seeks to bridge gaps in knowledge about sleep disturbances and neurodegeneration in DS-related Alzheimer’s disease.
Down syndromeAlzheimer's diseasesleep disturbancesgenetic mechanismscircadian regulationneuroinflammationAPPRCAN1neurodegenerationsynaptic function
Research Aims
3AIM 01Identify the effects of APP and RCAN1 gene dosage on sleep disturbances in a DS model.
AIM 02Investigate synaptic deficits linked to RCAN1 dosage correction in DS neurons.
AIM 03Understand the molecular mechanisms of sleep disruption using transcriptome analyses.
Skills the Lab Values
genetic manipulationelectrophysiologyimmunohistochemistrycell culturemulti-electrode array (MEA) recordingstranscriptome analysiscytokine assaysbehavioral assessmentsdata analysis in Rmouse models
Output against the department
Publications79bottom 22% of dept.202nd of 259
this lab
most publishedleast published
Citations6.3kbottom 33% of dept.173rd of 259
this lab
most citedleast cited
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