University of Pennsylvania · BiochemistryMarmorstein Lab
Ronen Marmorstein · Philadelphia, Pennsylvania
Research Focus
Dr. Ronen Marmorstein's lab at the University of Pennsylvania focuses on understanding how enzymes involved in metabolism, particularly ATP-citrate lyase (ACLY) and various acetyltransferases, contribute to cancer and other diseases. They study the molecular mechanisms behind how these enzymes are regulated and their role in producing important cellular metabolites. Their work aims to develop new drugs for cancer therapy by targeting these enzymes effectively.
ATP-citrate lyaseacetyltransferasecancer therapymetabolic regulationprotein acetylationenzymatic mechanismsdrug developmentpost-translational modification
Research Aims
4AIM 01Characterize the molecular mechanisms of metabolic regulation of ACLY.
AIM 02Identify potential inhibitors of ACLY for cancer treatment.
AIM 03Investigate the role of post-translational modifications in regulating enzyme activity.
AIM 04Explore the functional links between acetyl-CoA metabolism and cellular processes.
Skills the Lab Values
biochemical assayscryo-electron microscopyprotein purificationcell culture techniquesenzyme kineticsRNA analysisWestern blottingmetabolite profiling
Output against the department
Publications361top 16% of dept.63rd of 402
this lab
most publishedleast published
Citations23ktop 18% of dept.71st of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.