University of North Texas Health Science Center · Microbiology & ImmunologyCasali Lab
Paolo Casali · Fort Worth, Texas
Research Focus
Dr. Paolo Casali's lab focuses on understanding how epigenetics influences the immune response in diseases like systemic lupus erythematosus (SLE). They study how specific genes and environmental factors interact to affect B cell functions related to antibody production. This research aims to uncover potential new treatments for autoimmune diseases by targeting the mechanisms behind autoantibody production.
epigeneticsautoantibodieslupusB cell differentiationDNA recombinationgenetic regulationgene expressionhormonal influencesmetabolic cuestherapeutics
Research Aims
4AIM 01Investigate how Tet2 is regulated during different stages of B cell differentiation.
AIM 02Explore the role of Tet2 in promoting key genes necessary for antibody production.
AIM 03Examine dysregulation of Tet2 in B cells from lupus patients and mouse models to identify new therapeutic targets.
AIM 04Assess the impact of hormonal and nutritional factors on Tet2 expression and activity in B cells.
Skills the Lab Values
PCRB cell culturemouse modelsATAC-seqChIP-seqgene editing (CRISPR)flow cytometryRNA isolation and analysisbiostatisticsimmunohistochemistry
Output against the department
Publications807top 2% of dept.8th of 486
this lab
most publishedleast published
Citations52ktop 4% of dept.20th of 486
this lab
most citedleast cited
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