Princeton University · BiochemistrySilhavy Membrane Lab
Thomas J. Silhavy · Princeton, New Jersey
Research Focus
Dr. Thomas J. Silhavy's lab at Princeton University focuses on understanding how Gram-negative bacteria, like E. coli, construct and maintain their outer membrane. This work is crucial because the outer membrane acts as a protective barrier, and better understanding its biology can lead to new antibiotic treatments that target these bacteria. The lab studies various proteins and mechanisms involved in outer membrane biogenesis and transport, with an aim to uncover how these processes can be manipulated for potential therapeutic applications.
outer membrane biogenesisGram-negative bacteriaEscherichia colilipopolysaccharideantibiotic development
Research Aims
5AIM 01Investigate the mechanisms of outer membrane biogenesis in Gram-negative bacteria.
AIM 02Identify and characterize proteins involved in lipopolysaccharide assembly.
AIM 03Explore the role of chaperones in protein transport across membranes.
AIM 04Analyze the effects of mutations on membrane stability and function.
AIM 05Develop new antibiotics that exploit the outer membrane assembly processes.
Skills the Lab Values
protein purificationGenetic manipulationbacterial culture techniquesmutagenesislipid analysismicroscopy
Output against the department
Publications356top 16% of dept.66th of 402
this lab
most publishedleast published
Citations36ktop 8% of dept.31st of 402
this lab
most citedleast cited
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