University of California-Los Angeles · BiochemistryCenter for RNA-targeted Cancer Therapeutics
Feng Guo · Los Angeles, California
Research Focus
Dr. Feng Guo's lab focuses on discovering new cancer drugs that target specific RNA structures involved in cancer development. By using advanced techniques in crystallography, the lab aims to identify small molecules that can inhibit harmful RNA called microRNAs, which contribute to cancer. Their innovative approach could lead to breakthroughs in cancer treatment by designing therapies that are more effective and targeted.
drug discoverymicroRNAcancer therapycrystallographyfragment-based drug discovery
Research Aims
3AIM 01Execute fragment-based crystallographic screening against oncomiR precursors.
AIM 02Acquire and test an RNA-specific fragment library for drug discovery.
AIM 03Validate drug-like hits using biochemical and cellular assays.
Skills the Lab Values
high-throughput crystallographyfragment-based screeningRNA structure determinationsmall molecule designbiochemical assays
Output against the department
Publications225top 35% of dept.140th of 402
this lab
most publishedleast published
Citations16ktop 27% of dept.108th of 402
this lab
most citedleast cited
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