University of South Carolina-Columbia · PsychologyNeurocognitive Health and Restoration Lab
Charles F. Mactutus · Columbia, South Carolina
Research Focus
Dr. Charles Mactutus leads a research team at the University of South Carolina focusing on understanding and treating neurocognitive impairments in older adults with HIV. Their current project aims to develop new therapies that can restore brain function by targeting specific cellular pathways involved in neuronal health. The lab combines experimental work with innovative therapeutic approaches to address the pressing issue of cognitive decline associated with aging and HIV.
HIVneurocognitive impairmentagingdendritic spinesneurotherapeuticscognitive restorationestrogen receptorsNogoA signalingsynaptic integrity
Research Aims
3AIM 01Establish effective dendritic spine-targeted therapies for HIV-related neurocognitive disorders.
AIM 02Evaluate the in vivo efficacy of serine estrogen receptor beta agonists to improve cognitive function in aging populations.
AIM 03Investigate the neural mechanisms of therapeutic action of new drugs in animal models.
Skills the Lab Values
cell culture techniquesanimal modelsbehavioral testingpharmacological assaysmolecular biology techniquesdata analysisexperimental designneuroscience methodologieslongitudinal studies
Output against the department
Publications209top 32% of dept.94th of 296
this lab
most publishedleast published
Citations5.5kbottom 47% of dept.157th of 296
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.