University of Minnesota-Twin Cities · PharmacologyMore Opioid Lab
Swati S More · Minneapolis, Minnesota
Research Focus
Dr. Swati More's research lab focuses on understanding the role of angiotensin-converting enzyme (ACE) in the brain and its implications for opioid signaling. The lab aims to identify small molecules that can selectively inhibit ACE, potentially leading to new treatments for opioid use disorders without the adverse cardiovascular effects. The research involves innovative screening methods and behavioral assessments related to opioid rewards and addiction.
opioid signalingangiotensin-converting enzymesmall molecule inhibitorsfentanylnucleus accumbens
Research Aims
3AIM 01Screen a library of small molecules to find ACE inhibitors that selectively target the N-domain.
AIM 02Validate the effectiveness of selected compounds on MERF degradation in brain tissue.
AIM 03Evaluate the potential of lead compounds to reduce the rewarding effects of fentanyl.
Skills the Lab Values
liquid chromatography-tandem mass spectrometrywhole-cell voltage-clamp recordingsin vitro drug screeningmouse modelsdrug reward assessment
Output against the department
Publications64bottom 12% of dept.406th of 462
this lab
most publishedleast published
Citations1.8kbottom 11% of dept.409th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.