Massachusetts Institute of Technology · BiologyThe Interaction Dynamics Lab
Amy E Keating · Cambridge, Massachusetts
Research Focus
Dr. Amy E. Keating's lab at MIT focuses on understanding protein-protein interactions, which are critical for cellular functions and can play a role in diseases. The lab combines computational techniques with experimental methods to map these interactions, especially targeting short linear motifs that can bind to various proteins. By studying these interactions, the lab aims to uncover how specific proteins interact in healthy and disease states, which could lead to innovative therapies.
protein interactionshuman interactomeshort linear motifsdisease pathwaysautophagycancercomputational biologybiomedical research
Research Aims
5AIM 01Map and decode the human interactome to understand protein interactions.
AIM 02Identify specific interactions made by paralogous protein domains.
AIM 03Determine the sequence and structure features that regulate SLiM binding.
AIM 04Develop new models for predicting protein interactions.
AIM 05Design selective inhibitors for targeted protein-protein interactions.
Skills the Lab Values
computational modelingprotein engineeringcell culturehigh-throughput screeningdata analysisdeep learningexperimental designbiochemical assaysstructure prediction
Output against the department
Publications171top 39% of dept.399th of 1,033
this lab
most publishedleast published
Citations6.5kbottom 46% of dept.554th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.