University of Michigan-Ann Arbor · PhysiologyLiver Metabolism Research Lab
Lei Yin · Ann Arbor, Michigan
Research Focus
Dr. Lei Yin's lab at the University of Michigan focuses on understanding how a protein called ChREBP protects the liver from fatty liver diseases, particularly non-alcoholic steatohepatitis (NASH). By investigating the role of ChREBP in regulating fat metabolism and cell behavior in the liver, the lab aims to uncover new approaches to prevent and treat serious liver conditions. This research is vital since NASH is a significant health concern with limited treatment options.
NASHfatty liver diseaseChREBPhepatic stellate cellsfatty acid oxidation
Research Aims
3AIM 01Examine the role of hepatic ChREBP in protecting against diet-induced NASH through fatty acid oxidation.
AIM 02Determine how ChREBP suppresses the activation of hepatic stellate cells via secreted factors.
AIM 03Dissect the signaling pathways regulating ChREBP expression during NASH.
Skills the Lab Values
cell cultureRNA sequencinganimal modelsWestern blotin vitro assays
Output against the department
Publications140bottom 46% of dept.154th of 286
this lab
most publishedleast published
Citations6.8ktop 48% of dept.138th of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.