Baylor University · BiologyTumor Microenvironment and Immunology Lab
Jonathan Kelber · Waco, Texas
Research Focus
Dr. Jonathan Kelber's lab at Baylor University focuses on understanding how certain proteins influence the spread of cancer, especially in breast and pancreatic tumors. By studying how the Lipocalin-2 protein operates within tumors, the lab aims to uncover mechanisms that could lead to better treatments for metastatic cancers, which are particularly challenging to treat. This research could one day help design therapies to improve patient outcomes and enhance the effectiveness of immune therapies.
cancer metastasisLipocalin-2tumor immunologybreast cancerpancreatic cancertumor microenvironmentinflammationimmune therapyproteomicssingle-cell analysis
Research Aims
4AIM 01Investigate Lcn2's role in tumor cell invasion and its signaling mechanisms.
AIM 02Analyze how Lcn2 influences immune responses in the metastatic niche.
AIM 03Define the interactions between tumor cells and the immune system during metastasis.
AIM 04Identify new biomarkers for cancer therapy resistance.
Skills the Lab Values
cell cultureCRISPR technologyspinning disc microscopyconfocal microscopytransgenic modelstumor spheroid culturessingle-cell proteomicsgene expression analysisimmunohistochemistryallograft models
Output against the department
Publications136bottom 49% of dept.527th of 1,033
this lab
most publishedleast published
Citations2.5kbottom 18% of dept.848th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.