Boston University · BiologyTau Pathology and Neuroinflammation Lab
Jonathan D Cherry · Boston, Massachusetts
Research Focus
Dr. Jonathan D. Cherry's lab at Boston University Medical Campus focuses on understanding the effects of repetitive head injuries (RHI) on the brain, particularly concerning a condition known as chronic traumatic encephalopathy (CTE). The lab uses advanced techniques to study how tau protein accumulates in the brain after such injuries and how this influences neuroinflammation and neurodegeneration. Their research aims to elucidate the mechanisms linking RHI and tau pathology, hoping to lead to better treatments and diagnostic markers for CTE and related diseases.
chronic traumatic encephalopathytau pathologyneuroinflammationrepetitive head injuriesspatial transcriptomicssingle nuclei RNA sequencingbiomarkersbrain injurydisease modeling
Research Aims
5AIM 01Characterize the cellular response to tau in chronic traumatic encephalopathy.
AIM 02Examine the relationship between neuroinflammation and tau accumulation.
AIM 03Identify biomarkers for disease progression using postmortem human samples.
AIM 04Investigate mechanisms of neurodegeneration linked to repetitive head injuries.
AIM 05Develop better disease models for chronic traumatic encephalopathy.
Skills the Lab Values
single nuclei RNA sequencing (snRNAseq)spatial transcriptomicsELISA3D cortical spheroid culturehuman brain tissue analysisprotein aggregation assaysmicroscopydata analysismolecular profiling
Output against the department
Publications80bottom 23% of dept.790th of 1,033
this lab
most publishedleast published
Citations5.1kbottom 39% of dept.633rd of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.