UMCUniversity of Massachusetts Chan Medical School · Biology
Genetic Regulation and Development Unit
Thomas G Fazzio · Worcester, Massachusetts
Research Focus
Dr. Thomas Fazzio's lab focuses on understanding the genetic and epigenetic mechanisms that drive early mammalian development. They utilize cutting-edge techniques to identify and characterize genetic variants within regulatory elements that influence gene expression. The lab's work aims to clarify how these genetic changes affect cell fate decisions, ultimately contributing to our understanding of developmental disorders and improving regenerative medicine strategies.
gene regulationepigeneticscell fate decisionembryonic developmentsequence variants
Research Aims
3AIM 01Develop a method for identifying rare genetic variants in regulatory elements.
AIM 02Investigate the effects of genetic mutations on gene expression at the single cell level.
AIM 03Characterize the gene regulatory network involved in early embryonic cell fate decisions.
Skills the Lab Values
high-throughput sequencingsingle-cell RNA sequencingepigenetic profilingmolecular cloningcell culture
Output against the department
Publications87bottom 28% of dept.741st of 1,033
this lab
most publishedleast published
Citations4.3kbottom 33% of dept.692nd of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.