Harvard University · Microbiology & ImmunologyRubin Lab
Eric J. Rubin · Cambridge, Massachusetts
Research Focus
Dr. Eric J. Rubin's lab at Harvard University focuses on understanding and addressing the challenges posed by non-tuberculous mycobacteria (NTMs), which are responsible for difficult-to-treat chronic infections. The lab investigates the molecular mechanisms that lead to inherent drug resistance in these pathogens and aims to identify new strategies to enhance the effectiveness of existing antibiotics and develop novel treatment options. By utilizing advanced genetic techniques and culture models, the team seeks to uncover potential therapeutic targets that could facilitate better management of NTM infections.
non-tuberculous mycobacteriadrug resistanceantibiotic therapychronic infectionsmolecular mechanismstherapeutic targetsgenetic screeningtissue culture
Research Aims
4AIM 01Identify molecular mechanisms of drug resistance in non-tuberculous mycobacteria.
AIM 02Develop tissue culture models to study lung infections caused by NTMs.
AIM 03Explore genetic pathways that could resensitize NTMs to existing antibiotics.
AIM 04Determine effective therapeutic targets for treating chronic NTM infections.
Skills the Lab Values
cell culturegenetic screeningmolecular analysisantibiotic susceptibility testingpathogen isolationdata analysis with Pythonmicroscopychemical geneticsmodel organism studies
Output against the department
Publications849top 1% of dept.6th of 486
this lab
most publishedleast published
Citations29ktop 10% of dept.50th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.