Baylor College of Medicine · GeneticsCenter for Genetic Heart Research
Lilei Zhang · Houston, Texas
Research Focus
Dr. Lilei Zhang's lab at Baylor College of Medicine focuses on understanding genetic variations in the MYH7 gene, which are linked to heart diseases. The lab develops innovative methods for interpreting and validating these genetic variants using advanced technologies like single cell RNA sequencing and machine learning. This research aims to improve the diagnosis and treatment of cardiomyopathies and other hereditary conditions by providing deeper insights into how gene mutations affect heart cell function.
MYH7cardiomyopathymachine learningsingle cell RNA sequencinggenetic variants
Research Aims
3AIM 01Develop a high throughput system for variant molecular phenotyping in cardiomyocytes
AIM 02Validate the functional effects of MYH7 variants in heart cells
AIM 03Study the structure and function relationship of selected MYH7 variants.
Skills the Lab Values
cell cultureinduced pluripotent stem cells (iPSCs)RNA sequencingfunctional assaysmachine learning algorithms
Output against the department
Publications84bottom 24% of dept.196th of 259
this lab
most publishedleast published
Citations1.7kbottom 6% of dept.243rd of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.