University of Washington-Seattle Campus · PhysiologyGordon Pain Lab
Sharona E Gordon · Seattle, Washington
Research Focus
Dr. Sharona E. Gordon's lab at the University of Washington focuses on understanding how nerve growth factor (NGF) influences the behavior of TRPV1 ion channels, which are important for pain sensation. By employing innovative chemical biology techniques, the lab studies how NGF regulates the movement of TRPV1 channels to the cell membrane in response to inflammation. This research could identify new targets for pain management therapies.
TRPV1chemical biologyNGFcell traffickingpain management
Research Aims
4AIM 01Probe how NGF influences TRPV1 channel trafficking to the cell membrane
AIM 02Activate PI3K signaling directly to investigate TRPV1 feedback
AIM 03Examine the protein complex involving TrkA, PI3K, and TRPV1 using advanced imaging
AIM 04Create mutations in TRPV1 to study the significance of its interaction with PI3K
Skills the Lab Values
chemical biology techniquescell culturegene editingfluorescence microscopysingle-molecule imaging
Output against the department
Publications191top 36% of dept.101st of 286
this lab
most publishedleast published
Citations3.6kbottom 29% of dept.202nd of 286
this lab
most citedleast cited
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