University of Miami · Biomedical EngineeringGlioma Mechanisms Lab
Markus Bredel · Coral Gables, Florida
Research Focus
Dr. Markus Bredel's lab focuses on understanding the mechanisms behind gliomas, a type of aggressive brain tumor that originates from neural progenitor cells. The research explores how specific genetic alterations, particularly involving the NFKBIA gene, influence chromatin structure and gene regulation during the development of these tumors. By studying these processes, the lab aims to identify potential therapeutic targets for gliomas and decipher how neural cell differentiation can lead to cancer.
gliomasneural progenitor cellschromatin regulationNFKBIA genePRC2cell fateCRISPRglioblastomagene silencingneural differentiation
Research Aims
3AIM 01Investigate the role of NFKBIA in regulating chromatin dynamics during neural lineage specification.
AIM 02Characterize how NFKBIA influences PRC2 subcomplex assembly and function in glioma development.
AIM 03Determine the effects of genetic editing on cellular pathways leading to gliomagenesis from neural progenitor cells.
Skills the Lab Values
CRISPRcell culturegenome editingRNA sequencingchromatin immunoprecipitationflow cytometryWestern blottingmouse modelsbiochemical assaysnext-generation sequencing
Output against the department
Publications261top 37% of dept.221st of 595
this lab
most publishedleast published
Citations6.8ktop 48% of dept.288th of 595
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.