West Virginia University · PhysiologyCardiac Mitochondrial Health Lab
John M Hollander · Morgantown, West Virginia
Research Focus
Dr. John M. Hollander's lab at West Virginia University focuses on understanding the cellular mechanisms that lead to heart problems in individuals with type 2 diabetes. His research investigates how mitochondrial proteins are imported and refolded, processes that are often disrupted in diabetic hearts, resulting in poor heart function. By exploring these mechanisms, the lab aims to identify potential therapeutic strategies that can improve heart health in diabetic patients.
diabetesmitochondrial dysfunctionprotein importcardiac healthproteomicstype 2 diabetesheart failuremtHsp70LonP1therapeutic interventions
Research Aims
3AIM 01Investigate the locations within mitochondria where protein import is impaired in diabetic hearts.
AIM 02Evaluate how type 2 diabetes affects mitochondrial protein refolding and the role of mtHsp70 and LonP1.
AIM 03Determine the impact of compromised mitochondrial protein import on cardiac function and stress responses.
Skills the Lab Values
PCRcell culturemouse modelsWestern blotmitochondrial isolationprotein purificationimmunofluorescenceRNA extractionprotein refolding techniquesbiochemical assays
Output against the department
Publications219top 29% of dept.82nd of 286
this lab
most publishedleast published
Citations5.4kbottom 45% of dept.156th of 286
this lab
most citedleast cited
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