Johns Hopkins University · GeneticsMitochondrial Quality Control in Cardiomyocytes Lab
Hilary Vernon · Baltimore, Maryland
Research Focus
Dr. Hilary Vernon's lab at Johns Hopkins University focuses on understanding how mitochondrial function and quality control are regulated in heart cells, particularly in relation to Barth Syndrome. This research is critical because disruptions in mitochondrial maintenance can lead to serious heart problems. By exploring the effects of a specific genetic deficiency, her lab aims to uncover the underlying mechanisms of heart disease and develop potential new therapies.
Barth Syndromemitochondrial quality controlmitophagycardiomyocytesheart disease
Research Aims
3AIM 01Evaluate the role of TAZ deficiency on mitochondrial quality control mechanisms.
AIM 02Determine the impact of TAZ deficiency on mitophagy during cardiomyocyte development.
AIM 03Investigate how different genetic backgrounds influence heart function and mitophagy in TAZ-KO mice.
Skills the Lab Values
cell culturegenetic engineeringmouse modelsflow cytometryRNA sequencing
Output against the department
Publications138bottom 44% of dept.144th of 259
this lab
most publishedleast published
Citations3.3kbottom 17% of dept.215th of 259
this lab
most citedleast cited
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