University of South Florida · BiochemistryThe FKBP51 Project
Laura J Blair · Tampa, Florida
Research Focus
Dr. Laura J. Blair's lab at the University of South Florida studies the role of a protein called FKBP51 in Alzheimer's disease, particularly how it relates to neuropsychiatric symptoms like depression. The lab uses mouse models to investigate whether modifying FKBP51 can protect against nerve cell damage linked to tau protein accumulation. This research could enhance understanding of Alzheimer's progression and identify potential therapeutic targets for improving mental health in affected patients.
Alzheimer's Diseasetau proteinneuropsychiatric symptomsFKBP51mouse models
Research Aims
5AIM 01Study the role of FKBP51 in regulating tau accumulation
AIM 02Investigate the impact of FKBP51 inhibition on neuropsychiatric symptoms
AIM 03Determine the genetic variants associated with depression in Alzheimer's disease
AIM 04Explore molecular pathways linking FKBP51 to tau pathogenesis
AIM 05Assess protective effects of FKBP51 manipulation in mouse models of Alzheimer's disease
Skills the Lab Values
transgenic mouse modelsbehavioral assessmentin vivo experimentationmolecular biology techniqueselectrophysiology
Output against the department
Publications117bottom 31% of dept.276th of 402
this lab
most publishedleast published
Citations5.0kbottom 28% of dept.288th of 402
this lab
most citedleast cited
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