Yale University · Microbiology & ImmunologyHIV Persistence and Immune Evasion Lab
Ya-Chi Ho · New Haven, Connecticut
Research Focus
Dr. Ya-Chi Ho's lab at Yale University focuses on understanding how HIV-1 persists in the immune system, specifically in CD4+ T cells, which are critical for immune defense. Despite treatment, HIV-1 infected cells can survive and even proliferate, making it difficult to completely eliminate the virus. The lab uses advanced single-cell technologies to investigate the mechanisms behind HIV-1 persistence and how these infected cells evade immune responses, aiming to identify better therapeutic targets for HIV treatments.
HIV persistenceCD4+ T cellssingle-cell analysisimmune evasionclonal expansion
Research Aims
5AIM 01Investigate how HIV-1 persists in cytotoxic CD4+ T cells despite treatment.
AIM 02Examine clonal expansion dynamics of HIV-1-infected T cells.
AIM 03Profile immune programs that drive HIV-1 persistence.
AIM 04Identify specific markers for HIV-1-infected cells for targeted therapies.
AIM 05Study the effects of cytokines on the survival of HIV-infected cells.
Skills the Lab Values
single-cell ECCITEseqflow cytometrybioinformaticsmachine learningT-cell receptor sequencing
Output against the department
Publications72bottom 22% of dept.377th of 486
this lab
most publishedleast published
Citations7.7ktop 46% of dept.225th of 486
this lab
most citedleast cited
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