UTMThe University of Texas MD Anderson Cancer Center · Genetics
The Aldehyde Dynamics Lab
Georgios Karras · Houston, Texas
Research Focus
Dr. Georgios Karras's lab focuses on understanding how certain chemicals, known as aldehydes, can damage our DNA and proteins, leading to diseases like cancer. They investigate how these harmful substances disrupt essential protein functions and contribute to genetic instability. By uncovering these mechanisms, the lab aims to develop new strategies for managing diseases linked to aging and lifestyle choices, potentially leading to better diagnostic and treatment approaches.
aldehydesgenome instabilitycancerproteotoxic stressDNA repair
Research Aims
5AIM 01Investigate the effects of aldehyde-derived protein adducts on DNA repair proteins.
AIM 02Determine the mechanisms by which aldehydes impair protein folding.
AIM 03Evaluate the relationship between proteotoxic stress and genome instability.
AIM 04Develop new biomarkers for aldehyde-related diseases.
AIM 05Explore innovative strategies for managing genome instability in cancer.
Skills the Lab Values
Western blotcell culturemouse modelsDNA damage assaysproteomicsPCRgenomic sequencingbiostatisticsbioinformatics
Output against the department
Publications113bottom 36% of dept.166th of 259
this lab
most publishedleast published
Citations3.5kbottom 18% of dept.212th of 259
this lab
most citedleast cited
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