Ohio State University-Main Campus · ChemistryThe Protein Dynamics Lab
Christopher P Jaroniec · Columbus, Ohio
Research Focus
Dr. Christopher Jaroniec's lab at Ohio State University focuses on understanding how large protein and protein-nucleic acid complexes work in health and disease. They use cutting-edge techniques to look at the structures and dynamics of these complexes at an atomic level. Their research aims to uncover the roles of these complexes in gene regulation and the mechanisms behind various neurodegenerative diseases.
protein complexesnucleic acidsneurodegenerative diseaseschromatinamyloid structuresgene regulationstructural biologybiophysical techniquesNMRcryo-electron microscopy
Research Aims
5AIM 01Investigate the structural dynamics of nucleosomes and their interactions with chromatin-binding proteins.
AIM 02Explore the atomic-level structure of amyloid fibrils related to prion diseases.
AIM 03Assess the impact of post-translational modifications on nucleosome function.
AIM 04Develop advanced methods for studying large biomolecular assemblies.
AIM 05Provide insights into the molecular mechanisms of prion strain selection.
Skills the Lab Values
solid-state nuclear magnetic resonance (NMR)cryo-electron microscopyprotein biochemistryspectroscopic analysismolecular modelingcell culturechromatin immunoprecipitation (ChIP)sequence alignmentcomputational biologydata visualization
Output against the department
Publications117bottom 25% of dept.163rd of 216
this lab
most publishedleast published
Citations7.5kbottom 45% of dept.118th of 216
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.