Drexel University · Microbiology & ImmunologyHIV Cure Innovation Lab
Brian Wigdahl · Philadelphia, Pennsylvania
Research Focus
Dr. Brian Wigdahl's lab at Drexel University focuses on developing advanced gene editing strategies to combat HIV-1 infection, particularly in the body's various tissue reservoirs, including the brain. By utilizing CRISPR technology, the lab aims to enhance the precision and effectiveness of treatments targeting the diverse strains of HIV found in patients. Their innovative research combines high-throughput biological assays and computational biology to improve gene editing outcomes, ultimately seeking to provide a potential cure for HIV.
HIVgene editingCRISPRbrain reservoirsviral reservoirsHIV curemolecular recordershigh-throughput assayscomputational biologylentiviral vectors
Research Aims
3AIM 01Develop a model for predicting Cas:gRNA editing outcomes.
AIM 02Identify the functional impacts of different Cas:gRNA combinations on HIV.
AIM 03Test the efficacy of Cas:gRNA pairs in ex vivo and in vivo settings.
Skills the Lab Values
CRISPR gene editinghigh-throughput screeningcell culturemolecular cloningbioinformaticsanimal modelsflow cytometryRNA extractionDNA sequencingin vitro assays
Output against the department
Publications299top 17% of dept.81st of 486
this lab
most publishedleast published
Citations7.8ktop 46% of dept.222nd of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.