University of California-Berkeley · ChemistryThe Enzyme Dynamics Lab
Judith P Klinman · Berkeley, California
Research Focus
Dr. Judith P. Klinman's lab at UC Berkeley focuses on understanding how enzymes work at a molecular level, particularly how their movements influence their ability to catalyze chemical reactions quickly. The research involves studying the mechanics of enzymes, including those that are critical for producing important biological compounds. This work not only sheds light on basic biochemistry but also has practical implications, such as designing new antibiotics.
enzyme catalysisprotein motionsmechanistic studydrug targetingpost-translational modification
Research Aims
5AIM 01Explore the physical properties of enzymes to understand their function better.
AIM 02Investigate the rapid catalysis of bond cleavage in enzyme active sites.
AIM 03Study the TIM barrel family of enzymes for potential drug development.
AIM 04Analyze post-translational modifications in ribosomal peptides.
AIM 05Develop methods for redesigning proteins for new functions.
Skills the Lab Values
protein purificationenzyme kineticsspectroscopy techniquesmolecular modelingbiochemical assays
Output against the department
Publications462top 21% of dept.46th of 216
this lab
most publishedleast published
Citations24ktop 19% of dept.40th of 216
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.