University of California-Irvine · PhysiologyThe Retrosplenial Research Lab
Kevin T Beier · Irvine, California
Research Focus
Dr. Kevin T. Beier's research focuses on understanding how changes in the retrosplenial cortex, a specific brain region, contribute to the progression of Alzheimer's disease (AD). By studying both mouse models and human post-mortem samples, the lab aims to identify early indicators of AD and the molecular mechanisms involved. This research could lead to new therapeutic strategies to combat AD-related memory loss.
Alzheimer's Diseaseretrosplenial cortexAD pathogenesismemory deficitshyperexcitabilityneurosciencespatial memorytranscriptional changestherapeutic targets
Research Aims
4AIM 01Define how neuronal hyperexcitability in the retrosplenial cortex contributes to Alzheimer's-related memory deficits.
AIM 02Identify the timing of hyperexcitability emergence in retrosplenial cortex layer 5 cells in various AD mouse models.
AIM 03Characterize transcriptional changes in the retrosplenial cortex during AD progression in mouse models.
AIM 04Investigate molecular changes in human retrosplenial cortex tissues from AD patients and mild cognitive impairment cases.
Skills the Lab Values
mouse modelsimmunohistochemistryspatial transcriptomicsgene expression analysisbehavioral assaysdata analysismolecular biology techniquesneuron excitability studiesmemory assessment taskstissue collection techniques
Output against the department
Publications106bottom 31% of dept.196th of 286
this lab
most publishedleast published
Citations7.9ktop 41% of dept.118th of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.