University of Michigan-Ann Arbor · NeuroscienceTDP43 Pathology Research Lab
Sami Barmada · Ann Arbor, Michigan
Research Focus
Dr. Sami Barmada's lab at the University of Michigan focuses on understanding the role of a specific protein called TDP43 in neurodegenerative diseases like ALS and frontotemporal dementia. They investigate how certain shortened forms of TDP43 accumulate in neurons and contribute to disease. By studying these proteins in human tissues and using advanced techniques, the lab aims to uncover the origins of TDP43-related diseases and explore potential new treatments.
TDP43ALSfrontotemporal dementiaprotein aggregationRNA splicing
Research Aims
3AIM 01Establish how shortened TDP43 isoforms accumulate in hyperexcitable neurons.
AIM 02Investigate the relationship between TDP43 isoform deposition and neurodegenerative disease pathology in human tissues.
AIM 03Determine the physiological functions of these shortened TDP43 variants and their role in RNA homeostasis.
Skills the Lab Values
cell cultureRNA sequencingspatial transcriptomicsproteomicsgenetic manipulationmouse modelsimmunohistochemistrybioinformaticsmicroscopy
Output against the department
Publications148top 49% of dept.331st of 671
this lab
most publishedleast published
Citations9.1ktop 43% of dept.289th of 671
this lab
most citedleast cited
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