The University of Texas Health Science Center at San Antonio · BiochemistryThe SAMHD1 Immunity Lab
Dmitri N Ivanov · San Antonio, Texas
Research Focus
Dr. Dmitri N Ivanov's research focuses on understanding how a protein called SAMHD1 helps the body's immune system fight against HIV-1, the virus that causes AIDS. This protein regulates the levels of deoxynucleotides, which are vital for various cellular functions including DNA repair. His lab studies the biochemical properties and regulatory mechanisms of SAMHD1 to explore how it can enhance antiviral defense in non-dividing immune cells.
HIV-1SAMHD1innate immunitydeoxynucleotide metabolismantiviral mechanisms
Research Aims
5AIM 01Investigate how SAMHD1's enzymatic properties affect antiviral defense mechanisms.
AIM 02Explore the relationship between dNTP metabolism and susceptibility to HIV infection.
AIM 03Determine the structural basis of SAMHD1 regulation through allosteric mechanisms.
AIM 04Identify how posttranslational modifications influence SAMHD1 function.
AIM 05Characterize the molecular interactions between SAMHD1 and its substrates.
Skills the Lab Values
PCRprotein purificationenzyme kineticsX-ray crystallographycell culturemutagenesisbioinformaticsimmunological assaysmass spectrometry
Output against the department
Publications44bottom 6% of dept.377th of 402
this lab
most publishedleast published
Citations1.3kbottom 5% of dept.383rd of 402
this lab
most citedleast cited
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