Oregon Health & Science University · BiologyAndrogen ImmunoDynamics Lab
Amy E Moran · Portland, Oregon
Research Focus
Dr. Amy E. Moran's lab investigates how the androgen receptor affects T cell function, particularly in the context of cancer immunotherapy. They are exploring the mechanisms by which this receptor influences T cell behavior and its implications for improving treatment outcomes in cancers like prostate cancer. The research integrates animal models and chromosome-level analysis to better understand these processes and potentially augment immunotherapy effectiveness.
androgen receptorT cell differentiationimmunotherapyprostate cancercheckpoint blockadechromatingene expressionepigenetics
Research Aims
3AIM 01Evaluate the role of androgen receptor activity in repressing T cell effector genes.
AIM 02Determine how androgen receptor signaling contributes to a repressive chromatin state in dysfunctional CD8 T cells.
AIM 03Investigate if loss of T cell intrinsic androgen receptor enhances responsiveness to checkpoint blockade.
Skills the Lab Values
cell culturemouse modelschromatin immunoprecipitation (ChIP)DNA binding assaysreal-time PCRflow cytometryATAC-seqRNA sequencingbiopsy analysis
Output against the department
Publications126bottom 45% of dept.566th of 1,033
this lab
most publishedleast published
Citations4.3kbottom 32% of dept.699th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.