University of Alabama at Birmingham · BiologyEpigenetic Insights Lab
Elizabeth E Brown · Birmingham, Alabama
Research Focus
Dr. Elizabeth E. Brown's lab at the University of Alabama at Birmingham focuses on understanding how epigenetic changes in DNA influence the risk of developing certain blood disorders, particularly Monoclonal Gammopathy of Undetermined Significance (MGUS) and Multiple Myeloma (MM). By studying the DNA methylome, the lab aims to uncover biological markers linked to these conditions, which disproportionately affect African Americans. This research has the potential to improve clinical strategies for monitoring and managing these diseases.
epigeneticsMGUSmultiple myelomaDNA methylomebiomarkers
Research Aims
4AIM 01Characterize how DNA methylation influences the risk of MGUS in African American populations.
AIM 02Identify potential biomarkers for better risk assessment in MGUS and MM.
AIM 03Explore heritable changes in gene activity linked to past environmental exposures.
AIM 04Utilize high-quality clinical data to enhance understanding of MGUS/MM etiology.
Skills the Lab Values
DNA sequencingepigenome analysisbisulfite sequencingdata analysisbioinformatics
Output against the department
Publications181top 37% of dept.376th of 1,033
this lab
most publishedleast published
Citations8.6ktop 44% of dept.456th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.