Johns Hopkins University · GeneticsArking Mitochondria Lab
Dan E Arking · Baltimore, Maryland
Research Focus
Dr. Dan E Arking's lab at Johns Hopkins University focuses on understanding how mitochondria affect human health, especially in relation to aging and diseases like cardiovascular issues and dementia. They study the role of mitochondrial DNA and its variations, aiming to identify biomarkers and therapeutic targets that could improve health outcomes. Their research combines genetics, multi-omics data, and advanced methodologies to uncover insights into mitochondrial function and its implications for diseases.
mitochondriaagingbiomarkerscardiovascular diseasedementialipidomicssudden cardiac arrestgene variants
Research Aims
5AIM 01Identify novel biomarkers of mitochondrial function related to aging and disease.
AIM 02Determine the causal relationships between mitochondrial genetic variants and health outcomes.
AIM 03Explore the role of lipidomics in cognitive decline and Alzheimer's disease.
AIM 04Investigate the connection between mitochondrial function and sudden cardiac arrest risk.
AIM 05Validate findings through large biobanks and cohort studies.
Skills the Lab Values
PCRgenome-wide association studieslipidomics analysismetabolomicsproteomicshuman induced pluripotent stem cellsdata analysis using R or Pythoncell culturestatistical modeling
Output against the department
Publications407top 16% of dept.42nd of 259
this lab
most publishedleast published
Citations40ktop 15% of dept.40th of 259
this lab
most citedleast cited
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