Michigan State University · BiologyThe VWF Recovery Lab
James P Luyendyk · East Lansing, Michigan
Research Focus
Dr. James P. Luyendyk's lab studies how the blood protein von Willebrand Factor (VWF) affects the repair of liver injuries caused by an overdose of acetaminophen, a common pain medication. They aim to discover ways to enhance liver recovery by targeting VWF and its interactions with platelets. The lab works closely with a network of physician-scientists and utilizes advanced genetic models and therapeutic strategies to address acute liver failure, which currently has limited treatment options.
liver injuryacute liver failurevon Willebrand FactorVWF-targeted therapeuticsplateletsthrombolysisbiomarkersacetaminophenliver disease
Research Aims
3AIM 01Investigate the role of ADAMTS13 in acetaminophen-induced liver injury.
AIM 02Determine how VWF inhibits liver repair after acetaminophen exposure.
AIM 03Identify methods to degrade harmful VWF deposits to improve liver recovery.
Skills the Lab Values
genetically-modified mouse modelsVWF-targeted drug developmentthrombolytic therapybiochemical assaysclinical sample analysisflow cytometryWestern blotPCRdata analysis techniques
Output against the department
Publications180top 37% of dept.380th of 1,033
this lab
most publishedleast published
Citations6.9kbottom 48% of dept.542nd of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.