University of California-Irvine · BiochemistryThe Endocrine Nexus
Marcus Michael Seldin · Irvine, California
Research Focus
Marcus Michael Seldin's lab at UC Irvine focuses on understanding how different organs communicate with each other, particularly in the context of diseases like obesity and type 2 diabetes. By combining computational tools with experimental research, the lab aims to identify and validate new endocrine signaling pathways. This innovative integration of bioinformatics and experimental techniques will help uncover the mechanisms of organ communication and their implications in metabolic diseases.
endocrine communicationmetabolic diseasesobesitytype 2 diabetesbioinformaticsproteomicsin vivo experimentationhigh-throughput screeningmachine learning
Research Aims
5AIM 01Explore inter-organ signaling mechanisms in metabolic diseases.
AIM 02Develop computational tools to identify endocrine interactions.
AIM 03Validate findings through experimental and high-throughput methods.
AIM 04Investigate the implications of organ communication in obesity and diabetes.
AIM 05Enhance understanding of genetic variation in endocrine signaling.
Skills the Lab Values
proteomic analysisbioinformaticshigh-throughput screeningin vitro assaysmouse modelsBayesian networksgene expression analysiscomputational modelingdata visualization
Output against the department
Publications212top 37% of dept.150th of 402
this lab
most publishedleast published
Citations9.4kbottom 49% of dept.207th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.