University of Illinois Chicago · BiologyTau Therapeutics Lab
Scott Thomas Brady · Chicago, Illinois
Research Focus
Dr. Scott Brady's lab at the University of Illinois at Chicago focuses on understanding and developing treatments for neurodegenerative diseases, particularly those related to tau protein dysfunction like Alzheimer's and frontotemporal dementia. The lab is exploring how misfolded tau proteins disrupt normal brain functions and contributes to disease. By using chemical compounds to target specific mechanisms of tau toxicity, the lab aims to identify potential therapeutic strategies that could help restore neuronal function.
tauopathiesAlzheimer's Diseasefrontotemporal dementianeurodegenerationsmall molecule ligandstau signalingphosphorylationcell cultureneuronal function
Research Aims
4AIM 01Investigate how different posttranslational modifications of tau affect its function and pathology.
AIM 02Assess the role of tau mutations in disrupting pathways involved in neuronal signaling.
AIM 03Identify the molecular mechanisms by which tau regulates CK2 and JNK signaling pathways.
AIM 04Examine tau's physiological roles in neuronal development and function.
Skills the Lab Values
cell cultureimmunohistochemistryWestern blottingRNA sequencingmolecular dockingphenotypic assaysrodent modelsbiochemical assaysdata analysis with Python