Case Western Reserve University · PharmacologyIon Channel Dynamics Lab
Sudha Chakrapani · Cleveland, Ohio
Research Focus
Dr. Sudha Chakrapani's lab focuses on understanding the molecular workings of specific ion channels in the brain that are crucial for fast communication between nerve cells. By studying these channels, which play roles in vital bodily functions like movement and pain perception, the lab aims to find new ways to develop drugs that can effectively treat neurological disorders and chronic pain. They use advanced techniques to visualize these channels and determine how they are regulated in the body.
ion channelsallosteric mechanismsdrug developmentneurotransmitterspain perceptionmolecular dynamicsserotonin receptorsglycine receptorselectrophysiology
Research Aims
5AIM 01Determine the molecular basis of allosteric mechanisms in ligand-gated ion channels.
AIM 02Investigate the architecture and functional mechanisms of heteromeric pLGIC assemblies.
AIM 03Explore post-translational regulation of ion channels and their functional interactomes.
AIM 04Elucidate the molecular details of neurotransmitter recognition and channel gating.
AIM 05Develop novel therapeutic agents targeting pLGIC dysfunctions.
Skills the Lab Values
cryo-electron microscopymass spectrometryelectrophysiologyprotein dynamics measurementsmolecular dynamic simulationscell cultureligand binding assaysdata analysisstructural biology
Output against the department
Publications101bottom 25% of dept.345th of 462
this lab
most publishedleast published
Citations2.7kbottom 20% of dept.369th of 462
this lab
most citedleast cited
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