Dartmouth College · BiochemistryActin Mitochondrial Dynamics Lab
Henry N Higgs · Hanover, New Hampshire
Research Focus
Dr. Henry N Higgs' lab at Dartmouth College studies the dynamic interplay between the actin cytoskeleton and mitochondria in mammalian cells. The team focuses on understanding how transient actin structures influence mitochondrial function and energy metabolism, particularly in relation to diseases linked to dysfunctional mitochondria. Their research has significant implications for various cellular processes and could lead to insights in treating conditions such as Charcot-Marie-Tooth disease and focal segmental glomerulosclerosis.
actin cytoskeletonmitochondrial dynamicscell metabolismlive-cell microscopyprotein interactionsdisease mechanismsglycolysismitochondrial fission
Research Aims
5AIM 01Investigate how calcium activates the formin protein INF2 for actin polymerization.
AIM 02Examine how INF2-induced actin structures interact with mitochondrial fission proteins.
AIM 03Explore the impact of mitochondrial depolarization on actin structure formation.
AIM 04Determine the signaling pathways triggered by mitochondrial calcium release during actin dynamics.
AIM 05Assess how glycolysis is stimulated by actin networks in response to mitochondrial changes.
Skills the Lab Values
live-cell microscopyproteomicsmetabolomic analysisbiochemical reconstitutioncell culture techniquesfluorescence imaginggenetic manipulationdata analysis in biological systems
Output against the department
Publications197top 42% of dept.169th of 402
this lab
most publishedleast published
Citations16ktop 27% of dept.109th of 402
this lab
most citedleast cited
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